VMS Help SET, FILE, Qualifiers, /REMOVE  *Conan The Librarian (sorry for the slow response - running on an old VAX)

    Use with caution.

    Enables you to remove one of the names of a file that has more
    than one name, without deleting the file. If you have created an
    additional name for a file with the /ENTER qualifier of SET FILE,
    you can use the /REMOVE qualifier to remove either the original
    name or the alias. The file still exists and can be accessed by
    whatever name or names remain in effect.

    However, if you accidentally remove the name of a file that
    has only one name, you cannot access that file with most DCL
    commands; use the ANALYZE/DISK_STRUCTURE utility to retrieve the
    file.