Bio::Tools::Run::Phylo::PAML::Yn00 man page on Pidora

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Bio::Tools::Run::PhyloUserMContributed PeBio::Tools::Run::Phylo::PAML::Yn00(3)

NAME
       Bio::Tools::Run::Phylo::PAML::Yn00 - Wrapper aroud the PAML program
       yn00

SYNOPSIS
	 use Bio::Tools::Run::Phylo::PAML::Yn00;
	 use Bio::AlignIO;
	 my $alignio = Bio::AlignIO->new(-format => 'phylip',
					-file	=> 't/data/gf-s85.phylip');
	 my $aln = $alignio->next_aln;

	 my $yn = Bio::Tools::Run::Phylo::PAML::Yn00->new();
	 $yn->alignment($aln);
	 my ($rc,$parser) = $yn->run();
	 while( my $result = $parser->next_result ) {
	   my @otus = $result->get_seqs();
	   my $MLmatrix = $result->get_MLmatrix();
	   # 0 and 1 correspond to the 1st and 2nd entry in the @otus array
	   my $dN = $MLmatrix->[0]->[1]->{dN};
	   my $dS = $MLmatrix->[0]->[1]->{dS};
	   my $kaks =$MLmatrix->[0]->[1]->{omega};
	   print "Ka = $dN Ks = $dS Ka/Ks = $kaks\n";
	 }

DESCRIPTION
       This is a wrapper around the yn00 (method of Yang and Nielsen, 2000)
       program of PAML (Phylogenetic Analysis by Maximum Likelihood) package
       of Ziheng Yang.	See http://abacus.gene.ucl.ac.uk/software/paml.html
       for more information.

       This module will generate a proper yn00.ctl file and will run the
       program in a separate temporary directory to avoid creating temp files
       all over the place and will cleanup after itself.

FEEDBACK
   Mailing Lists
       User feedback is an integral part of the evolution of this and other
       Bioperl modules. Send your comments and suggestions preferably to the
       Bioperl mailing list.  Your participation is much appreciated.

	 bioperl-l@bioperl.org			- General discussion
	 http://bioperl.org/wiki/Mailing_lists	- About the mailing lists

   Support
       Please direct usage questions or support issues to the mailing list:

       bioperl-l@bioperl.org

       rather than to the module maintainer directly. Many experienced and
       reponsive experts will be able look at the problem and quickly address
       it. Please include a thorough description of the problem with code and
       data examples if at all possible.

   Reporting Bugs
       Report bugs to the Bioperl bug tracking system to help us keep track of
       the bugs and their resolution. Bug reports can be submitted via the
       web:

AUTHOR - Jason Stajich
       Email jason-at-bioperl.org

CONTRIBUTORS
       Additional contributors names and emails here

APPENDIX
       The rest of the documentation details each of the object methods.
       Internal methods are usually preceded with a _

   Default Values
       See the Bio::Tools::Run::Phylo::PAML::Codeml module for documentation
       of the default values.

   program_name
	Title	: program_name
	Usage	: $yn00->program_name()
	Function: holds the program name
	Returns:  string
	Args	: None

   program_dir
	Title	: program_dir
	Usage	: $yn00->program_dir()
	Function: returns the program directory, obtained from ENV variable.
	Returns:  string
	Args	:

   new
	Title	: new
	Usage	: my $obj = Bio::Tools::Run::Phylo::PAML::Yn00->new();
	Function: Builds a new Bio::Tools::Run::Phylo::PAML::Yn00 object
	Returns : Bio::Tools::Run::Phylo::PAML::Yn00
	Args	: -alignment => the L<Bio::Align::AlignI> object
		  -save_tempfiles => boolean to save the generated tempfiles and
				     NOT cleanup after onesself (default FALSE)

   run
	Title	: run
	Usage	: $yn->run();
	Function: run the yn00 analysis using the default or updated parameters
		  the alignment parameter must have been set
	Returns : 3 values,
		  $rc = 1 for success, 0 for errors
		  hash reference of the Yang calculated Ka/Ks values
			   this is a set of pairwise observations keyed as
			   sequencenameA->sequencenameB->datatype
		  hash reference same as the previous one except it for the
		  Nei and Gojobori calculated Ka,Ks,omega values
	Args	: none

   error_string
	Title	: error_string
	Usage	: $obj->error_string($newval)
	Function: Where the output from the last analysus run is stored.
	Returns : value of error_string
	Args	: newvalue (optional)

   alignment
	Title	: alignment
	Usage	: $codeml->align($aln);
	Function: Get/Set the L<Bio::Align::AlignI> object
	Returns : L<Bio::Align::AlignI> object
	Args	: [optional] L<Bio::Align::AlignI>
	Comment : We could potentially add support for running directly on a file
		  but we shall keep it simple
	See also: L<Bio::SimpleAlign>

   get_parameters
	Title	: get_parameters
	Usage	: my %params = $self->get_parameters();
	Function: returns the list of parameters as a hash
	Returns : associative array keyed on parameter names
	Args	: none

   set_parameter
	Title	: set_parameter
	Usage	: $codeml->set_parameter($param,$val);
	Function: Sets a codeml parameter, will be validated against
		  the valid values as set in the %VALIDVALUES class variable.
		  The checks can be ignored if on turns of param checks like this:
		    $codeml->no_param_checks(1)
	Returns : boolean if set was success, if verbose is set to -1
		  then no warning will be reported
	Args	: $paramname => name of the parameter
		  $value     => value to set the parameter to
	See also: L<no_param_checks()>

   set_default_parameters
	Title	: set_default_parameters
	Usage	: $codeml->set_default_parameters(0);
	Function: (Re)set the default parameters from the defaults
		  (the first value in each array in the
		   %VALIDVALUES class variable)
	Returns : none
	Args	: boolean: keep existing parameter values

Bio::Tools::Run::Wrapper methods
   no_param_checks
	Title	: no_param_checks
	Usage	: $obj->no_param_checks($newval)
	Function: Boolean flag as to whether or not we should
		  trust the sanity checks for parameter values
	Returns : value of no_param_checks
	Args	: newvalue (optional)

   save_tempfiles
	Title	: save_tempfiles
	Usage	: $obj->save_tempfiles($newval)
	Function:
	Returns : value of save_tempfiles
	Args	: newvalue (optional)

   outfile_name
	Title	: outfile_name
	Usage	: my $outfile = $codeml->outfile_name();
	Function: Get/Set the name of the output file for this run
		  (if you wanted to do something special)
	Returns : string
	Args	: [optional] string to set value to

   tempdir
	Title	: tempdir
	Usage	: my $tmpdir = $self->tempdir();
	Function: Retrieve a temporary directory name (which is created)
	Returns : string which is the name of the temporary directory
	Args	: none

   cleanup
	Title	: cleanup
	Usage	: $codeml->cleanup();
	Function: Will cleanup the tempdir directory after a PAML run
	Returns : none
	Args	: none

   io
	Title	: io
	Usage	: $obj->io($newval)
	Function:  Gets a L<Bio::Root::IO> object
	Returns : L<Bio::Root::IO>
	Args	: none

perl v5.14.1			  2011-07Bio::Tools::Run::Phylo::PAML::Yn00(3)
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